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MaaT Microbiome Restoration Biotherapeutic

Development stage: Unknown
Lead developer: MaaT Pharma
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Cell Therapies, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Rectal, Oral

Overview

MaaT Microbiome Restoration Biotherapeutic (MMRB) is a platform technology developed by MaaT Pharma. This platform is used to create full-ecosystem, live biotherapeutic products derived from pooled healthy donor intestinal ecosystems. These therapies, characterized by high microbial species diversity, are designed to restore gut microbiome functionality and re-establish immune system homeostasis. The platform's leading product candidates, MaaT013 (enema) and MaaT033 (oral capsule), are being developed to treat life-threatening conditions associated with cancer treatments and stem cell transplantation, such as acute Graft-versus-Host Disease (GvHD), acute myeloid leukemia (AML), and high-risk myelodysplastic syndrome (MDS). The products have received Orphan Drug Designation from the FDA and EMA.

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