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MABS-140

Development stage: Preclinical
Lead developer: Manhattan Biosolutions
Modality: Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
Administration: Intravenous, Subcutaneous, Intratumoral

Overview

MABS-140 is a preclinical-stage RNA interference (RNAi) therapeutic candidate being developed by Manhattan BioSolutions. The drug is designed to target "panRNA" for the treatment of orphan diseases. As an RNAi-based therapy, MABS-140 likely utilizes small interfering RNAs (siRNAs) to silence the expression of specific genes by mediating the degradation of target mRNA. While the program is featured in the company's development pipeline, specific details regarding the exact molecular nature of the panRNA target or the primary orphan indication have not been extensively disclosed in public literature.

Targets

KSHV (Kaposi's sarcoma-associated herpesvirus)

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