Drug intelligence / Profile preview

maca root

Development stage
Phase 3
Modality
Small Molecules
Administration
Oral
01

Overview

Maca root is the tuberous root of *Lepidium meyenii*, a plant native to the high Andes of Peru. Traditionally used as both food and medicine for over 3,000 years, it is consumed in various forms including powder and extracts. Maca contains bioactive compounds such as macamides, macaenes, glucosinolates, alkaloids, and flavonoids[7][6]. Its mechanism of action is not fully understood but may involve modulation of hormone levels (including estrogenic activity), antioxidant effects (radical scavenging), anti-inflammatory properties, neuroprotection via attenuation of oxidative stress and neurotransmitter modulation (noradrenergic/dopaminergic systems), fatty acid amide hydrolase inhibition by macamides (affecting neurotransmitter release), and possible adaptogenic effects supporting stress response[7][9][5]. Primary indications include traditional use for enhancing fertility in men and women (improving sperm quality/count/motility; increasing libido; alleviating menopausal symptoms such as hot flashes or mood swings)[2][4][6][8]. Other purported benefits include improved energy/stamina/endurance performance[8], mood enhancement[5], cognitive support/memory improvement[8], bone health/osteoporosis prevention[6], cardiovascular health support[5], anti-inflammatory/antioxidant/neuroprotective actions[7]. However, robust clinical evidence for these uses remains limited.

Brand names
Maca Magic
Other names
Peruvian ginsengGinseng Andinmaca powder
02

Targets

FAAHCYP1A2 (Cytochrome P450 1A2)CYP3A4 (Cytochrome P450 3A4)

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