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Drug intelligence / Profile preview
MACH-1 FAP colon cancer vaccine
- Development stage
- Preclinical
- Lead developer
- Orlance
- Modality
- Prophylactic Vaccines → Vaccines & Immunotherapeutics, Gene Therapies, DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Epidermal
01
Overview
MACH-1 FAP colon cancer vaccine is a preclinical nucleic acid (DNA) vaccine being developed by Orlance for the treatment and prevention of Familial Adenomatous Polyposis (FAP) and associated colon cancer. The vaccine utilizes Orlance's proprietary MACH-1 (Micro-particle Accelerated Cell Harnessing) platform, which is an epidermal powdered gene gun delivery system. This technology delivers DNA-coated gold microparticles directly into the skin's epidermal layer, targeting Langerhans cells to induce a potent and systemic immune response. By delivering the genetic material directly into the cytoplasm of cells in the skin, the platform aims to overcome the delivery challenges typically associated with traditional DNA vaccines, potentially offering a more effective immunotherapy for colorectal malignancies.
- Other names
- Orlance FAP vaccineMACH-1 epidermal DNA vaccine for FAPMACH1 epidermal DNA vaccine for FAPMACH 1 epidermal DNA vaccine for FAP
02
Targets
FAP (Fibroblast activation protein alpha)
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