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macrocarpal B
- Development stage
- Preclinical
- Lead developer
- Peking University
- Modality
- Small Molecules
01
Overview
Macrocarpal B is a natural phloroglucinol-sesquiterpene adduct isolated from *Eucalyptus* species, such as *Eucalyptus globulus* and *Eucalyptus macrocarpa*. It has historically been studied for its antibacterial properties against pathogens like methicillin-resistant *Staphylococcus aureus* (MRSA) and those causing periodontal disease. More recently, researchers at Peking University identified macrocarpal B as a potent small-molecule inhibitor of the interaction between the M-type phospholipase A2 receptor (PLA2R) and anti-PLA2R autoantibodies, which are key drivers of primary membranous nephropathy (MN). By binding directly to PLA2R, macrocarpal B prevents autoantibody binding and mitigates podocyte injury, representing a novel therapeutic candidate for the treatment of membranous nephropathy.
- Other names
- Macrocarpal B
02
Targets
PLA2R1 (Phospholipase A2 receptor 1)
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