Drug intelligence / Profile preview

macrogol + sodium sulfate anhydrous + sodium chloride + potassium chloride + sodium hydrogen carbonate + simeticone

Development stage
Unknown
Lead developer
Odense Universitetshospital
Modality
Implantable Hydrogels → Hydrogel Systems → Drug Delivery Systems, Small Molecules, Non-biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Injectable Hydrogels → Hydrogel Systems → Drug Delivery Systems
Administration
Oral
01

Overview

This combination drug consists of a polyethylene glycol (macrogol) based osmotic laxative, a balanced electrolyte solution (including sodium sulfate, sodium chloride, potassium chloride, and sodium hydrogen carbonate), and the anti-foaming agent simeticone. Developed and studied by researchers at Odense University Hospital, this specific combination is used to prevent or treat postoperative constipation, particularly in elderly patients following hip fracture surgery. The macrogol and sodium sulfate components work by retaining water in the bowel through osmosis, thereby increasing stool volume and stimulating peristalsis. The electrolytes are included to ensure that the large volume of fluid does not cause significant shifts in the patient's systemic electrolyte balance. Simeticone is added to reduce the surface tension of gas bubbles in the gastrointestinal tract, alleviating bloating and discomfort often associated with constipation and the use of osmotic laxatives.

Other names
Laxabon + Simeticonmacrogol 3350 with electrolytes and simeticonemacrogol3350 with electrolytes and simeticonemacrogol-3350 with electrolytes and simeticone

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