Mafusol

Mafusol is an approved, intravenously administered crystalloid infusion solution with antihypoxic, rehydrating, and detoxifying properties. Developed by the Russian Research Institute of Hematology and Transfusiology and manufactured by Firm Medpolymer and Biosintez, Mafusol is a combination of sodium fumarate, sodium chloride, potassium chloride, and magnesium chloride. The primary active component, sodium fumarate, acts as an antihypoxic agent by entering the tricarboxylic acid (Krebs) cycle, where it is metabolized to support ATP synthesis and maintain cellular energy production under conditions of oxygen deficiency. Mafusol is indicated for the treatment of hypovolemic and hypoxic states, including acute blood loss, shock (hemorrhagic, burn, traumatic, and operative), severe intoxication (such as peritonitis or sepsis), and ischemic stroke. It is also used as a perfusion component to fill the cardiopulmonary bypass circuit during cardiac surgery.

Brand names

MafusolМафусол

Other names

magnesium chloride + potassium chloride + sodium chloride + sodium fumaratepotassium chloride + magnesium chloride + sodium chloride + sodium fumarateкалия хлорид + магния хлорид + натрия хлорид + натрия фумаратнатрия фумарат + натрия хлорид + калия хлорид + магния хлорид