Drug intelligence / Profile preview

Magnacet

Development stage
Phase 4
Lead developer
Shionogi
Modality
Small Molecules
Administration
Oral
01

Overview

Magnacet is a combination analgesic consisting of oxycodone hydrochloride and acetaminophen. Oxycodone is a semi-synthetic opioid agonist that targets mu-opioid receptors in the central nervous system to inhibit ascending pain pathways and alter the perception of pain. Acetaminophen is a non-opioid analgesic and antipyretic that is believed to inhibit prostaglandin synthesis, primarily within the central nervous system, thereby increasing the pain threshold. This combination is indicated for the management of moderate to severe pain. Originally marketed by Victory Pharma, the product was acquired by Shionogi in 2011; however, the Magnacet brand has since been discontinued in the United States, although generic equivalents remain available.

Brand names
Magnacet
Other names
oxycodone + acetaminophenoxycodone hydrochloride + acetaminophen
02

Targets

MOR (Mu opioid receptor)PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)

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