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Drug intelligence / Profile preview
Magnaderm
- Development stage
- Unknown
- Lead developer
- ANHOX HEALTHCARE
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
Magnaderm is a topical combination pharmaceutical product developed and marketed by Anhox Healthcare. It is primarily formulated as a cream or ointment containing three active small molecule ingredients: beclometasone dipropionate (a corticosteroid), clotrimazole (an antifungal), and gentamicin (an aminoglycoside antibiotic). The beclometasone component acts as a glucocorticoid receptor agonist to reduce inflammation and itching; clotrimazole inhibits lanosterol 14-alpha demethylase to disrupt fungal cell membrane synthesis; and gentamicin binds to the 30S ribosomal subunit to inhibit bacterial protein synthesis. This triple-action formulation is indicated for the treatment of various inflammatory skin disorders complicated by bacterial or fungal infections, including eczema, contact dermatitis, ringworm, and cutaneous candidiasis. A variant formulation of the product may substitute betamethasone for beclometasone as the corticosteroid component.
- Brand names
- Magnaderm
02
Targets
Bacterial RibosomeGR (Glucocorticoid receptor)CYP51A1 (Sterol 14α-demethylase)
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