magnesium adenosine triphosphate

Magnesium adenosine triphosphate is a magnesium-coordinated ATP preparation, also described as ATP-magnesium or ATP-MgCl2. Mg-ATP is the physiologically relevant ATP complex that serves as a substrate and cofactor for ATP-dependent enzymes and cellular energy-dependent processes. When administered extracellularly in experimental settings, it can act as a purinergic agonist; in a murine polymicrobial-sepsis model, Mg-ATP activated macrophage P2X7 receptors and improved bacterial clearance, inflammation control, and survival. Historical preclinical and limited early clinical investigations evaluated intravenous ATP-MgCl2 for shock, ischemia, and ischemia-reperfusion injury, but it is not an identified approved pharmaceutical product or branded therapeutic program. ([pmc.ncbi.nlm.nih.gov](https://pmc.ncbi.nlm.nih.gov/articles/PMC4550379/))

Other names

adenosine 5'-triphosphate magnesium saltadenosine triphosphate-magnesium chlorideATP magnesiumATP magnesium saltATP-MgCl2ATP-MgCl-2ATP-MgCl 2magnesium ATPmagnesium-adenosine triphosphateMg-ATP