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magnesium beta-hydroxybutyrate
- Development stage
- Preclinical
- Lead developer
- Ketone Labs
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Magnesium beta-hydroxybutyrate is a *synthetic salt* combining the mineral magnesium with beta-hydroxybutyrate (BHB), a ketone body. BHB is produced endogenously during periods of low carbohydrate intake or fasting and acts as an alternative energy substrate, especially for the brain and muscle. Exogenously, magnesium beta-hydroxybutyrate may be used as a dietary supplement to *induce ketosis*, support energy metabolism, enhance cognitive and neurological function, and provide muscle and cardioprotective benefits. The compound's mechanism of action lies in BHB's ability to serve as an energy source, modulate inflammation by inhibiting the NLRP3 inflammasome, antagonize FFAR3, inhibit histone deacetylases (HDAC1, HDAC3, HDAC4) leading to changes in gene expression, and affect potassium channels and transporter modulation. Magnesium itself supports muscle and nerve function. Magnesium beta-hydroxybutyrate is primarily proposed as a dietary supplement rather than a pharmaceutical drug[1][2][3][4][6][8].
- Brand names
- magnesium beta-hydroxybutyrate
- Other names
- magnesium BHBmagnesium beta-OHBmagnesium β-hydroxybutyrate
02
Targets
KATP channel (ATP-sensitive potassium channel)HCAR2 (Hydroxycarboxylic acid receptor 2)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)HDAC (HDAC family)
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