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Magnesium cation (Mg2+) is an essential divalent mineral cation that serves as a critical cofactor for over 300 enzymatic systems, including those responsible for protein synthesis, muscle and nerve function, blood glucose control, and blood pressure regulation. It is required for energy production, oxidative phosphorylation, and glycolysis, and it contributes to the structural development of bone. In clinical practice, magnesium is administered via various salts (e.g., sulfate, chloride, oxide) for the treatment of hypomagnesemia, cardiac arrhythmias such as Torsades de Pointes, and the prevention of seizures in eclampsia and pre-eclampsia. Research also highlights its role as a bioactive signal in regenerative medicine, particularly in bone tissue engineering where it promotes vascularization and osteogenesis, and its potential neuroprotective effects in conditions like Parkinson's disease.
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