magnesium citrate + metronidazole hydrochloride + neomycin sulfate

This is a combination drug regimen consisting of magnesium citrate, metronidazole hydrochloride, and neomycin sulfate. It is primarily used as part of preoperative bowel preparation for patients undergoing elective colorectal surgery. Magnesium citrate acts as an osmotic laxative to induce catharsis and clear the bowel. Metronidazole hydrochloride and neomycin sulfate are oral antibiotics; metronidazole targets anaerobic bacteria by disrupting DNA synthesis, while neomycin is an aminoglycoside antibiotic that inhibits protein synthesis in susceptible bacteria. The combined use of these agents aims to reduce the risk of surgical site infections (SSIs) by both mechanical cleansing (magnesium citrate) and reduction of colonic bacterial load (metronidazole and neomycin)[1][9]. This regimen has been shown to significantly decrease SSI rates in colorectal surgery patients[1].