magnesium dithiosalicylate

Magnesium dithiosalicylate is a **salicylate derivative** that was evaluated as an anti-inflammatory agent. In a controlled clinical trial, 3 g daily showed anti-inflammatory effectiveness comparable to aspirin (3 g) in the treatment of rheumatoid arthritis, with significant reductions in morning stiffness, tender joints, pain score, and erythrocyte sedimentation rate. However, magnesium dithiosalicylate was associated with a high frequency of side effects, particularly hypersensitivity reactions, making it clinically unacceptable for the treatment of rheumatoid arthritis. Its mechanism of action is presumed similar to that of other salicylates, likely involving **nonselective inhibition of cyclooxygenase (COX-1 and COX-2)**, thereby reducing prostaglandin synthesis and inflammation[2].