magnesium glucoheptonate

Magnesium glucoheptonate is an organic salt of magnesium used primarily for oral magnesium supplementation. In the clinical context of the MAGNOLIA trial (Magnesium Replacement in Critically Ill Patients) conducted at Scarborough General Hospital, it is utilized as an oral option for protocolized magnesium replacement in the intensive care unit (ICU). The trial investigates whether targeting a higher serum magnesium level (0.85–0.95 mmol/L) using agents like magnesium glucoheptonate, magnesium oxide, and magnesium sulfate improves 30-day survival and reduces the incidence of atrial fibrillation in critically ill patients compared to lower targets. Magnesium is a vital intracellular cation that serves as a cofactor for over 300 enzymatic reactions, including those involved in ATP metabolism, protein synthesis, and the maintenance of cardiac rhythm and vascular tone.

Brand names

Rougier Magnesium

Other names

Magnesium glucoheptonateMagnesium D-glycero-D-gulo-heptonate