Drug intelligence / Profile preview

Magnesium malate

Development stage
Unknown
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Magnesium malate is a compound formed by combining magnesium, an essential mineral, with malic acid. It is commonly used as a dietary supplement to prevent or treat magnesium deficiency and to support overall health. Magnesium plays a crucial role in numerous biochemical reactions in the body, including energy production (as a cofactor for ATP synthesis), nerve function, muscle contraction, blood glucose control, and bone health[1][3][5][8]. Malic acid may enhance the absorption of magnesium and contribute to cellular energy production via the Krebs cycle[1][5]. Magnesium malate is noted for its high bioavailability compared to some other forms of magnesium supplements[1][5]. It has been studied for potential benefits such as supporting muscle health, reducing inflammation, improving exercise tolerance, relieving symptoms of depression and chronic pain (including fibromyalgia), promoting regular bowel movements (laxative effect), acting as an antacid for heartburn relief, and possibly aiding sleep quality[1][3][5][7]. The mechanism of action primarily involves replenishing systemic magnesium levels; at the cellular level it acts as a cofactor in enzymatic processes related to metabolism and vascular tone regulation[6][8].

Other names
magnesium malate
02

Targets

CaV (Voltage-gated calcium channel protein complex)ATP1A (Sodium/potassium-transporting ATPase)

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