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magnesium sulfate + diclofenac

Development stage: Approved
Modality: Small Molecules
Administration: Intravenous, Intramuscular

Overview

A combination of magnesium sulfate and diclofenac used primarily for pain management. Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory, and antipyretic properties[6][8], while magnesium sulfate is used as an anticonvulsant and electrolyte replenisher[3]. When used together, intravenous magnesium sulfate with intramuscular diclofenac has shown superior pain relief in renal colic compared to diclofenac alone, though the improvement was below accepted thresholds for clinical importance[5].

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)

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