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magnesium sulphate + normal saline
- Development stage
- Unknown
- Lead developer
- Aretaieion University Hospital
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
Magnesium sulphate + normal saline is a combination therapy being investigated for its anesthetic and analgesic effects in patients undergoing elective laparoscopic cholecystectomy. Magnesium sulphate functions as a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor and a blocker of voltage-gated calcium channels, mechanisms that contribute to its ability to modulate pain signaling and reduce the need for perioperative opioids. In this clinical trial setting, it is administered intravenously as a bolus followed by a continuous infusion, with normal saline (0.9% sodium chloride) serving as the diluent and vehicle. The study, led by Aretaieion University Hospital, aims to evaluate the impact of this regimen on recovery outcomes and postoperative pain management.
- Other names
- magnesium sulfate + 0.9% sodium chloridemagnesium sulphate + saline
02
Targets
VDCC (L-type voltage-dependent calcium channel (often specified further as subunits such as CaV1.2 in humans))NMDAR (Glutamate receptor ionotropic, NMDA)
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