magnetic nano-liposomes

Magnetic nano-liposomes (MNL) are a theranostic nanoplatform designed for tumor-targeted drug delivery, multi-modal imaging, and thermal therapy. Developed by researchers at Northeastern University and the Massachusetts College of Pharmacy and Health Sciences, these liposomes encapsulate superparamagnetic iron oxide nanoparticles (SPIONs) within a lipid bilayer composed of DPPC, DOTAP, cholesterol, and DOPE-PEG5000. The SPION core enables magnetic targeting to tumor sites using external magnets, provides contrast enhancement for MRI (T2/T2*), and allows for the generation of localized hyperthermia or thermal ablation when exposed to alternating current (AC) magnetic fields. Additionally, MNLs can be radiolabeled with isotopes such as Indium-111 for SPECT/CT imaging, facilitating real-time monitoring of biodistribution and treatment response in indications like melanoma and breast cancer.

Other names

magnetic nanoplatformsSPION-incorporated liposomes