magnoflorine

Magnoflorine is a quaternary isoquinoline alkaloid widely distributed in various medicinal plants, including *Magnolia officinalis*, *Phellodendron amurense*, *Tinospora cordifolia*, and *Corydalis* species. It exhibits a broad spectrum of pharmacological activities, including anti-inflammatory, antioxidant, neuroprotective, and anti-tumor effects. Mechanistically, magnoflorine has been shown to inhibit the NF-κB and MAPK signaling pathways, suppress ALOX15-mediated ferroptosis, and activate the PI3K/AKT pathway. It is currently being investigated in preclinical models for its potential therapeutic applications in osteoarthritis, cerebral ischemia-reperfusion injury (stroke), coronary heart disease, and exercise-induced fatigue. Additionally, it has shown promise in remodeling lipid metabolism in the tumor microenvironment of prostate cancer.

Other names

(S)-magnoflorinealpha-magnoflorineMagnoflorine