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magnolia biondii flower bud
- Development stage
- Phase 2
- Lead developer
- China Traditional Chinese Medicine
- Modality
- Small Molecules
- Administration
- Oral, Topical, Intranasal
01
Overview
Magnolia biondii flower bud, known as Xin Yi in Traditional Chinese Medicine, is a botanical drug primarily used for the treatment of respiratory conditions such as allergic rhinitis, sinusitis, and nasal congestion. Its therapeutic effects are attributed to a variety of bioactive compounds, including lignans like magnolin and fargesin, as well as volatile oils. The mechanism of action involves the inhibition of inflammatory mediators, such as histamine release from mast cells, and the suppression of pro-inflammatory cytokines like tumor necrosis factor (TNF) and interleukin-6 (IL-6). It also exhibits calcium channel blocking activity and anti-PAF (platelet-activating factor) effects, which contribute to its anti-allergic and anti-inflammatory profile. While widely used in East Asian medicine, it is often categorized as a dietary supplement or herbal medicine in Western regulatory frameworks.
- Other names
- Xin YiXin Yi HuaFlos MagnoliaeBiond Magnolia Flower Bud
02
Targets
MAPK3 (Mitogen-activated protein kinase 1)IL-6 (Interleukin 6)STAT3 (Signal Transducer and Activator of Transcription 3)PTAFR (Platelet-activating factor receptor)
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