Drug intelligence / Profile preview

magnolia officinalis

Development stage
Unknown
Modality
Small Molecules
Administration
Oral, Topical
01

Overview

Magnolia officinalis is a species of magnolia tree native to China and widely used in traditional Chinese medicine. The bark (and sometimes leaves and flowers) contains active polyphenolic compounds—primarily magnolol and honokiol—which are believed responsible for its medicinal effects. Traditionally used for anxiety, depression, stress relief, sleep disorders, gastrointestinal issues (such as indigestion and constipation), inflammation-related conditions (including arthritis), respiratory ailments (asthma), headaches, fever management, weight loss support and oral health. Preclinical studies suggest that the main constituents have anti-inflammatory effects by inhibiting inflammatory mediators such as substance P and prostaglandin E2; antioxidant properties via scavenging reactive oxygen species; antimicrobial activity; antidiabetic actions through improved insulin sensitivity; neuroprotective effects; anxiolytic/antidepressant activity likely via modulation of neurotransmitter systems or stress hormones; anticancer potential through inhibition of NF-kB signaling pathways affecting tumor growth/metastasis/angiogenesis. Human clinical data are limited but suggest possible benefits for menopausal symptoms (when combined with other agents), oral health (gingivitis reduction), weight management support and hepatic fat reduction in non-alcoholic fatty liver disease[1][2][3][4][5][8].

Other names
Magnolia barkHou PoCortex Magnoliae OfficinalisHo-No-KiIndian BarkJapanese whitebark magnoliaXin Ye HuaXin Yi Hua
02

Targets

GABRR (GABA-A receptor subunit rho)PPARG (Peroxisome proliferator-activated receptor gamma)BACE1 (Beta-site APP-cleaving enzyme 1)PKC (Protein kinase C family)PTGES (Microsomal prostaglandin E synthase-1)MAPK3 (Mitogen-activated protein kinase 1)

Beyond the preview

Go deeper on magnolia officinalis.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Full profile access

Follow clinical development from study design and recruitment through results.

  • Trial phase
  • Status
  • Readouts

Indications & development

Full profile access

Explore development by indication, patient population, and geography.

  • Indications
  • Development status
  • Countries

Licensing & deals

Full profile access

Trace asset ownership, licensing agreements, and commercial partnerships.

  • Partners
  • Deal terms
  • Milestones

Patents & exclusivity

Full profile access

Explore the patent landscape and regulatory exclusivity around an asset.

  • Patents
  • Expiration dates
  • Exclusivity

Competitive landscape

Full profile access

Compare development programs by target, modality, and indication.

  • Competing assets
  • Targets
  • Development stage

Research & analysis

Full profile access

Connect source evidence and development news to your research questions.

  • Publications
  • News
  • Analysis

Bring the full picture into focus.

See how Gosset can support your research on magnolia officinalis.

Explore the full profile

Gosset Free

Get started with Gosset.

Enter your work email and we’ll be in touch with next steps.

Work email preferred.

Book a call