Drug intelligence / Profile preview

magnolia officinalis

Development stage
Unknown
Modality
Small Molecules
Administration
Oral, Topical
01

Overview

Magnolia officinalis is a species of magnolia tree native to China and widely used in traditional Chinese medicine. The bark (and sometimes leaves and flowers) contains active polyphenolic compounds—primarily magnolol and honokiol—which are believed responsible for its medicinal effects. Traditionally used for anxiety, depression, stress relief, sleep disorders, gastrointestinal issues (such as indigestion and constipation), inflammation-related conditions (including arthritis), respiratory ailments (asthma), headaches, fever management, weight loss support and oral health. Preclinical studies suggest that the main constituents have anti-inflammatory effects by inhibiting inflammatory mediators such as substance P and prostaglandin E2; antioxidant properties via scavenging reactive oxygen species; antimicrobial activity; antidiabetic actions through improved insulin sensitivity; neuroprotective effects; anxiolytic/antidepressant activity likely via modulation of neurotransmitter systems or stress hormones; anticancer potential through inhibition of NF-kB signaling pathways affecting tumor growth/metastasis/angiogenesis. Human clinical data are limited but suggest possible benefits for menopausal symptoms (when combined with other agents), oral health (gingivitis reduction), weight management support and hepatic fat reduction in non-alcoholic fatty liver disease[1][2][3][4][5][8].

Other names
Magnolia barkHou PoCortex Magnoliae OfficinalisHo-No-KiIndian BarkJapanese whitebark magnoliaXin Ye HuaXin Yi Hua
02

Targets

BACE1 (Beta-site APP-cleaving enzyme 1)GABRR (GABA-A receptor subunit rho)MAPK3 (Mitogen-activated protein kinase 1)PTGES (Microsomal prostaglandin E synthase-1)PPARG (Peroxisome proliferator-activated receptor gamma)PKC (Protein kinase C family)MEKNF-κBPGE2 (Prostaglandin E2)SP (Substance P)

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