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MagSense HER2 Imaging Agent
- Development stage
- Unknown
- Lead developer
- Imagion Biosystems
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Nanoparticles → Drug Delivery Systems
- Administration
- Intradermal
01
Overview
MagSense HER2 Imaging Agent (MSH2IA) is a targeted molecular MRI contrast agent developed by Imagion Biosystems for the non-invasive detection of axillary lymph node metastasis in patients with HER2-positive (HER2+) breast cancer. The agent consists of a superparamagnetic iron oxide nanoparticle (SPION) core coated with biocompatible polymers and functionalized with the monoclonal antibody trastuzumab. Trastuzumab specifically targets the Human Epidermal Growth Factor Receptor 2 (HER2) expressed on breast cancer cells. Following peritumoral injection, the nanoparticles migrate through the lymphatic system to the axillary lymph nodes. If HER2+ cancer cells are present, the agent binds to them, creating a localized change in the magnetic field that is detectable via MRI. This technology aims to provide a more accurate and less invasive alternative to surgical staging or biopsy of the axilla.
- Brand names
- MagSense
- Other names
- HER2-magnetic nanoparticle-based molecular MRI imaging agentHER-2-magnetic nanoparticle-based molecular MRI imaging agentHER 2-magnetic nanoparticle-based molecular MRI imaging agent
02
Targets
ERBB2 (Erb-b2 receptor tyrosine kinase 2)
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