Drug intelligence / Profile preview

Mahakool

Development stage
Unknown
Lead developer
Grevis Pharma
Modality
Small Molecules
Administration
Ophthalmic, Topical
01

Overview

Mahakool is a multi-ingredient topical ophthalmic formulation developed and marketed by Grevis Pharma. It is primarily used as a decongestant and lubricant to treat ocular redness and irritation. The formulation contains **naphazoline hydrochloride** (0.05%) and **phenylephrine hydrochloride**, both of which are small molecule alpha-adrenergic agonists that induce vasoconstriction of the conjunctival blood vessels to reduce redness. It also includes **chlorpheniramine maleate**, an antihistamine that provides relief from allergic symptoms, and **carboxymethylcellulose** (CMC), which serves as a lubricant for dry eye conditions. The addition of camphor and menthol provides a cooling sensation upon application. Mahakool is indicated for allergic conjunctivitis, conjunctival hyperemia, and general eye strain or burning sensations.

Brand names
Mahakool
Other names
Naphazoline hydrochloride + Phenylephrine hydrochloride + Chlorpheniramine maleate + Carboxymethylcellulose + Camphor + Menthol
02

Targets

ADRA2A (α2A)ADRA1A (α1A)

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