mahonia fortunei extract

Mahonia fortunei extract is a botanical product derived from the Chinese Mahonia plant, a species traditionally utilized in Chinese herbal medicine (CHM). Recent systems pharmacology and multi-omics research has identified this extract as a potential therapeutic candidate for hepatocellular carcinoma (HCC). The extract contains various bioactive alkaloids, such as berberine, which contribute to its pharmacological profile. It exerts anti-cancer effects by modulating specific hub genes, including AKR1B10, HMGCR, and THBS1, and influencing critical signaling pathways such as TNF, IL-17, and MAPK. Functional assays indicate that the extract suppresses the proliferation and migration of HCC cells while simultaneously inducing apoptosis and ferroptosis, suggesting a multi-target mechanism of action suitable for precision ethnopharmacology.

Other names

Mahonia fortunei (Lindl.) Fedde extractChinese Mahonia extract