mahuang fuzi xixin decoction

Mahuang Fuzi Xixin decoction (MFXD) is a classic traditional Chinese medicine (TCM) formula, first described in the ancient text "Shang Han Lun" (Treatise on Cold Damage Diseases). [2, 4] It is a combination of three herbs: Herba Ephedrae (Mahuang), Radix Aconiti Lateralis Praeparata (Fuzi, processed Aconite root), and Radix et Rhizoma Asari (Xixin). [1] Traditionally, it is used to treat conditions characterized by Yang deficiency with externally contracted wind-cold. [3, 12] Modern pharmacological studies and clinical trials are investigating its efficacy for a range of conditions, including respiratory diseases like allergic rhinitis, bronchial asthma, and COVID-19 infection, as well as neuropathic pain and lung cancer. [1, 8, 9, 10, 11] The decoction's therapeutic effects are attributed to its complex chemical composition, which exerts synergistic anti-inflammatory, antiallergic, analgesic, and immunomodulatory activities. [1, 12] Network pharmacology studies suggest its mechanism involves modulating multiple signaling pathways, including the Fc epsilon RI, B-cell receptor, Toll-like receptor, TNF, NF-κB, and PI3K/AKT pathways. [1, 6]

Other names

Mahuang Xixin Fuzi DecoctionModified Mahuang-Fuzi-Xixin Decoction麻黄附子细辛汤ma-huang-fu-zi-xi-xin-tangMFXDMHFZXXDDecoction of Ephedra, Asarum and Aconite