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Mahuang Shengma Decoction (Mahuang Shengma Tang) is a classic Traditional Chinese Medicine (TCM) formula originally documented in the *Shanghan Lun* (Treatise on Febrile Diseases). It is a multi-herb decoction traditionally used to treat complex patterns involving both heat and cold, often manifesting as persistent fever, throat distress, and diarrhea. In modern clinical research, the formula is being investigated for the treatment of active ulcerative colitis (UC). The Affiliated Hospital of Xuzhou Medical University has conducted clinical trials comparing its efficacy to mesalazine, evaluating its ability to induce clinical and histopathological remission. The decoction is hypothesized to exert its therapeutic effects by modulating the intestinal microecology (gut microbiota) and regulating mucosal immune responses, specifically targeting inflammatory pathways associated with UC.
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