Malaria Challenge-U.S. Army Medical Research and Development Command

This is a controlled human malaria infection (CHMI) model developed by the U.S. Army Medical Research and Development Command (USAMRDC). It utilizes live *Plasmodium vivax* sporozoites, delivered via the bites of experimentally infected *Anopheles dirus* mosquitoes, to induce malaria in healthy, malaria-naive volunteers. This biological challenge system is primarily employed in Phase 1 clinical trials to assess the efficacy of candidate malaria vaccines (such as VMP001/AS01B) and new antimalarial drugs. The model provides a standardized, reproducible, and safe environment to study *P. vivax*, which is otherwise difficult to research due to the lack of a continuous in vitro culture system. Participants are closely monitored for the development of parasitemia and are treated with curative doses of chloroquine and primaquine upon diagnosis.

Other names

P. vivax Sporozoite Challenge ModelPlasmodium vivax sporozoite challengeControlled Human Malaria InfectionCHMI