malaria vaccine 257049 + AS01B

malaria vaccine 257049 + AS01B is a combination product comprised of the malaria vaccine candidate "257049", which is synonymous with the RTS,S antigen, formulated together with the AS01B adjuvant system. The RTS,S antigen is a recombinant protein targeting the circumsporozoite protein (CSP) of *Plasmodium falciparum*, aiming to elicit both humoral and cellular immune responses. AS01B is a liposome-based adjuvant that combines 3-*O*-desacyl-4'-monophosphoryl lipid A (MPL) and the saponin QS-21 to enhance the immune response by stimulating innate immunity, leading to strong and persistent CSP-specific antibody and T cell responses. The combination has been developed for the prevention of *Plasmodium falciparum* malaria, with clinical trials conducted primarily in children and infants in malaria-endemic regions[1][2][4].

Other names

RTS,S/AS01B