MALAT1 antisense oligonucleotide

MALAT1 antisense oligonucleotides (ASOs) are synthetic single-stranded nucleic acids designed to target and degrade the long non-coding RNA (lncRNA) Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1). MALAT1 is highly conserved and abundantly expressed in various tissues, but is significantly upregulated in multiple cancers, where it promotes tumor growth, metastasis, and drug resistance. MALAT1 ASOs typically function as gapmers (such as those utilizing locked nucleic acid [LNA], constrained ethyl [cEt], or 2'-O-methoxyethyl [MOE] modifications) that hybridize to complementary MALAT1 RNA sequences, triggering RNase H1-mediated cleavage and subsequent degradation of the target lncRNA. These agents are being investigated preclinically and in early-stage development for oncological indications (such as triple-negative breast cancer, multiple myeloma, and lung cancer) as well as serving as valuable research tools for studying ASO biodistribution and pharmacokinetics in the central nervous system and ocular tissues.

Other names

MALAT1 ASOMALAT-1 ASOMALAT 1 ASOanti-MALAT1 ASOanti-MALAT-1 ASOanti-MALAT 1 ASO