Drug intelligence / Profile preview

mallotus oppositifolius extract

Development stage
Preclinical
Lead developer
University of Ghana
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Mallotus oppositifolius extract (MOE) is a botanical extract prepared from the leaves of *Mallotus oppositifolius*, a shrub native to tropical Africa. Developed primarily by researchers at the University of Ghana, the extract is being investigated for its neuroprotective, anti-aggressive, and antidepressant-like properties. Preclinical studies suggest that its therapeutic effects are mediated through the modulation of the gut-brain axis (altering the relative abundance of gut microbiota such as *Lactobacilli*, *Desulfovibrio*, and *Parabacteroides*), enhancement of serotonergic neurotransmission (increasing serotonin levels in the prefrontal cortex and hippocampus), and inhibition of the glycine/NMDA receptor complex.

Other names
Mallotus oppositifolius leaf extracthydroethanolic leaf extract of Mallotus oppositifoliusmethanolic leaf extract of Mallotus oppositifolius
02

Targets

5-HT2 (5-HT2 receptor family)NMDAR (Glutamate receptor ionotropic, NMDA)

Beyond the preview

Go deeper on mallotus oppositifolius extract.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

  • Trial phase
  • Status
  • Readouts

Indications & development

Explore development by indication, patient population, and geography.

  • Indications
  • Development status
  • Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

  • Partners
  • Deal terms
  • Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

  • Patents
  • Expiration dates
  • Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

  • Competing assets
  • Targets
  • Development stage

Research & analysis

Connect source evidence and development news to your research questions.

  • Publications
  • News
  • Analysis

Bring the full picture into focus.

See how Gosset can support your research on mallotus oppositifolius extract.

Gosset Free

Get started with Gosset.

Enter your corporate email.

Work email preferred.

Book a call