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mammaglobin-A DNA vaccine
- Development stage
- Phase 1
- Lead developer
- Washington University School of Medicine
- Modality
- DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Prophylactic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
A cancer vaccine composed of a plasmid encoding the mammaglobin-A gene, designed to stimulate an immune response against breast cancer cells that overexpress the mammaglobin-A protein. The mechanism of action involves introducing the gene for mammaglobin-A via a closed circular DNA plasmid, leading to expression of this tumor-associated antigen and subsequent activation of CD8+ cytotoxic T cells and CD4+ helper T cells specific for mammaglobin-A. This immunostimulatory effect aims to enhance antitumor immunity in patients with breast cancer. Clinical trials have demonstrated safety and induction of MAM-A-specific T cell responses in patients with metastatic or early-stage breast cancer[1][2][3][5]. The primary indication is breast cancer.
- Other names
- mammaglobin-A DNA vaccineMAM-A DNA vaccine
02
Targets
SCGB2A2 (Mammaglobin-A)
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