Man3-siRNA

Man3-siRNA is a synthetic small interfering RNA (siRNA) conjugated with a trimannose (Man3) ligand, designed for targeted gene silencing via the RNA interference pathway. The Man3 ligand is intended to direct the siRNA specifically to cells expressing mannose receptors (for example, antigen-presenting cells or macrophages), enhancing cellular uptake through receptor-mediated endocytosis. Once internalized, the siRNA duplex is incorporated into the RNA-induced silencing complex (RISC), which then uses the antisense strand to bind complementary messenger RNA (mRNA), facilitating its cleavage and degradation. This prevents protein translation and results in targeted gene knockdown. Man3-siRNA is a research or preclinical agent leveraging synthetic siRNA for selective, sequence-dependent inhibition of gene expression at the mRNA level[1][2][3][4][5][6][7].