Drug intelligence / Profile preview

Mandibular Block-Ege University

Development stage
Unknown
Lead developer
Ege University
Modality
Small Molecules
Administration
Injection
01

Overview

Mandibular Block-Ege University refers to a specific intervention arm in a clinical trial conducted by Ege University, evaluating the efficacy of different anesthesia techniques in paediatric dentistry. This arm involves the administration of 1 mL of lidocaine using the traditional inferior alveolar nerve block (IANB) technique, delivered via a conventional dental syringe and a 27-gauge long needle. Lidocaine is an amide-type local anesthetic that functions by blocking voltage-gated sodium channels, thereby preventing the depolarization of nerve membranes and the subsequent conduction of pain impulses. In this study, the technique is used as a standard-of-care comparator to assess the performance of computer-controlled intraosseous anesthesia systems in children aged 6 to 12 years.

Other names
Mandibular BlockInferior Alveolar Nerve BlockIANBlidocaine
02

Targets

SCN1A (Voltage-gated sodium channel protein type 1 subunit alpha)SCN9A (Sodium channel protein type 9 subunit alpha)

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