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manganese chlorin e6
- Development stage
- Preclinical
- Lead developer
- Nanjing University of Posts and Telecommunications
- Modality
- Small Molecules
- Administration
- Intratumoral, Intravenous
01
Overview
Manganese chlorin e6 (Mn-Ce6) is a research-stage metallo-chlorin compound consisting of the chlorin e6 macrocycle coordinated with a manganese ion. It is widely investigated as a multifunctional theranostic agent and an artificial cofactor. In oncology research, Mn-Ce6 is utilized in various nanoplatforms (such as nanocomplexes, hydrogels, and liposomes) to enable dual photodynamic therapy (PDT) and chemodynamic therapy (CDT) under near-infrared (NIR) laser irradiation, generating reactive oxygen species (ROS) to induce immunogenic cell death. Additionally, the released manganese ions act as potent adjuvants that activate the cGAS-STING pathway, promoting type I interferon secretion and robust antitumor immunity. Mn-Ce6 also serves as a paramagnetic contrast agent for magnetic resonance imaging (MRI) and has been explored for thrombolytic and neuroprotective applications in ischemic stroke models. In biocatalysis, myoglobin reconstituted with Mn-Ce6 exhibits enhanced peroxidase-like catalytic efficiency.
- Other names
- manganese(II) chlorin e6Mn-chlorin e6
02
Targets
STING (Stimulator of interferon genes protein)Cyclic GMP–AMP synthase
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