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manganese-engineered Lactobacillus reuteri
- Development stage
- Preclinical
- Lead developer
- Huazhong University of Science and Technology
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
**Manganese-engineered Lactobacillus reuteri** is an experimental oral live biotherapeutic product for colorectal cancer. The product consists of *Lactobacillus reuteri* surface-engineered with manganese to enhance bacterial proliferation, glycerol metabolism, gastrointestinal survival, colorectal-tumor colonization, and production of antitumor metabolites, principally reuterin. In preclinical colorectal cancer models, MnLR was administered with glycerol as a metabolic substrate; this MnLR/Gly regimen promoted intratumoral bacterial and metabolite accumulation, selective tumor-cell killing, immunogenic cell death, dendritic-cell maturation, M1 macrophage polarization, and effector T-cell responses. The program remains preclinical; an enteric capsule formulation of MnLR plus glycerol, termed GlyMnLR, was evaluated in orthotopic rabbit colorectal cancer models. ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/41413024/))
- Other names
- manganese-engineered L. reuteriMnLR
02
Targets
GLUD1 (Glutamate dehydrogenase 1, mitochondrial)
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