Drug intelligence / Profile preview

mangiferonic acid

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

Mangiferonic acid is a cycloartane-type triterpenoid primarily isolated from plants in the genus *Mangifera*, such as the common mango (*Mangifera indica*) and the Bambangan (*Mangifera pajang*). It is a bioactive phytochemical that has demonstrated a range of pharmacological activities in preclinical studies, including antioxidant, anti-inflammatory, and anti-diabetic effects. Specifically, it has been investigated for its ability to inhibit alpha-glucosidase, suggesting potential utility in managing postprandial hyperglycemia. Additionally, mangiferonic acid has shown cytotoxic properties against several cancer cell lines, including breast and colon cancer, potentially through the induction of apoptosis and inhibition of NF-kappaB signaling pathways. It is currently categorized as a nutraceutical or research compound rather than an approved pharmaceutical agent.

Other names
3-oxocycloart-24-en-26-oic acidMangiferonic acid
02

Targets

NF-κBSucrase-Isomaltase

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