Drug intelligence / Profile preview

Mango

Development stage
Unknown
Lead developer
Mangoceuticals
Modality
Small Molecules
Administration
Oral
01

Overview

The name "Mango" refers to both a branded pharmaceutical product for men's health and the fruit *Mangifera indica*, which is utilized as a therapeutic dietary intervention. As a pharmaceutical, "Mango" is a brand of erectile dysfunction (ED) medication developed by Mangoceuticals, Inc., typically marketed through a telemedicine platform. As a nutraceutical intervention, mango fruit is rich in bioactive polyphenols, including gallotannins and mangiferin. Clinical research indicates that regular mango consumption can significantly increase insulin sensitivity and improve the disposition index in individuals with overweight or obesity and chronic low-grade inflammation, potentially through the activation of the Nrf2 antioxidant defense pathway. Additionally, mango has been studied as an adjuvant therapy for inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, where it has demonstrated the ability to reduce pro-inflammatory biomarkers (such as IL-6 and TNF-α), decrease serum endotoxin levels, and modulate the gut microbiota to favor beneficial probiotic bacteria.

Brand names
Mango
Other names
Mangifera indicaKent mangoKeitt mango
02

Targets

Oxytocin receptorNOS1 (nNOS)PDE5 (Phosphodiesterase 5A)

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