Drug intelligence / Profile preview

mango peel extract

Development stage
Preclinical
Administration
Oral
01

Overview

Mango peel extract is a natural extract derived from the outer skin of the mango fruit (Mangifera indica), prepared typically via solvent extraction (such as ethanol or aqueous methods) from the dried peel. It contains high levels of **bioactive compounds** including mangiferin (a C-glucosyl xanthone), polyphenols, flavonoids, protocatechuic acid, gallic acid, quercetin 3-O-galactoside, penta-O-galloyl-glucoside, β-carotene, and other phenolics[1][3][5]. These substances confer **potent antioxidant, anti-inflammatory, antimicrobial, anti-diabetic, and anti-carcinogenic properties**[1][3][5]. Mechanisms of action reported in preclinical studies include inhibition of carbohydrate-hydrolyzing enzymes (α-amylase and α-glucosidase), enhancement of antioxidant enzyme activities (SOD, CAT, GPx, GST), increased plasma insulin levels, and free radical scavenging effects[1][3][5]. The extract is being explored as a **nutraceutical**, in functional foods, and as a dietary supplement for potential benefits such as reduction of blood glucose, protection against oxidative stress, and reduction in risk of chronic diseases including diabetes, cancer, cardiovascular disorders, and neurodegenerative diseases[1][3].

Other names
mango skin extractMangifera indica peel extract
02

Targets

NeuraminidaseGST (Glutathione S-transferase alpha 3)GPX4 (Glutathione peroxidase 4)Misfolded SOD1AMY (Pancreatic alpha-amylase)Sucrase-Isomaltase

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