Mannose 6-phosphate

Mannose 6-phosphate (M6P) is a crucial biological molecule that serves as a targeting signal for lysosomal hydrolases, facilitating their delivery to lysosomes. This process is primarily mediated by mannose 6-phosphate receptors (MPRs), including the cation-independent mannose 6-phosphate receptor (CI-MPR or CIM6P/IGF2R) and the cation-dependent mannose 6-phosphate receptor (CD-MPR). Dysregulation of M6P signaling and its receptors is implicated in various diseases, such as lysosomal storage disorders like Mucolipidosis type II (MLII) and Mannose 6-phosphate isomerase deficiency (MPI-CDG), as well as conditions like Sonic hedgehog medulloblastoma, Angelman syndrome, hepatic senescence, liver fibrosis, and melanoma. Therapeutic strategies often involve modulating the M6P pathway, targeting its receptors, or administering related compounds like D-mannose or prodrugs such as PMP1.

Brand names

Juvidex

Other names

M6PM-6PM 6P