Mansoura Univ. EGFR-TKWT compound 6a

Mansoura Univ. EGFR-TKWT compound 6a: sourced facts only. name: "The obtained results revealed that compound 6a displayed strong inhibitory activity against EGFR-TKWT (IC50 = 0.078 μM) that closely approximates the reference drug erlotinib and promising inhibitory activity against topoisomerase IIα (IC50 = 12.6 μM) surpassing that of etoposide." [PMID:41418598]; target: "The obtained results revealed that compound 6a displayed strong inhibitory activity against EGFR-TKWT (IC50 = 0.078 μM) that closely approximates the reference drug erlotinib and promising inhibitory activity against topoisomerase IIα (IC50 = 12.6 μM) surpassing that of etoposide." [PMID:41418598]; developer: "Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt." [PMID:41418598]; stage: "Moreover, human epidermoid carcinoma (A431) and non-small cell lung cancer (NSCLC) (H1975) cells were utilized to assess the in vitro cytotoxicity of compound 6a and it showed good activity over A431 and H1975 cells (IC50 = 7.89 and 13.11 μM, respectively) compared to erlotinib." [PMID:41418598]