Drug intelligence / Profile preview

Mansoura Univ. VEGFR-2 compound 6a

Development stage
Preclinical
Lead developer
Mansoura University
01

Overview

Mansoura Univ. VEGFR-2 compound 6a: sourced facts only. name: "Multikinase screening of the most potent VEGFR-2 inhibitors, compounds 6a and 6f, demonstrated appreciable inhibitory activity against the tested kinases, including EGFR, PDGFR-β and c-Met." [PMID:42442295]; target: "Multikinase screening of the most potent VEGFR-2 inhibitors, compounds 6a and 6f, demonstrated appreciable inhibitory activity against the tested kinases, including EGFR, PDGFR-β and c-Met." [PMID:42442295]; developer: "Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt." [PMID:42442295]; stage: "In vivo anti-HCC assay for the most cytotoxic compound 6a demonstrated a reduction in liver weight comparable to sorafenib, and 6a-treated group presented lower serum level of AST and ALT compared to the untreated-HCC group." [PMID:42442295]

02

Targets

VEGFR2 (Vascular endothelial growth factor receptor 2)

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