Drug intelligence / Profile preview

maoto extract

Development stage
Unknown
Lead developer
Tsumura
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Maoto (TJ-27) is a traditional Japanese Kampo medicine composed of four botanical extracts: Ephedra Herb, Apricot Kernel, Cinnamon Bark, and Glycyrrhiza Root. Developed and manufactured by Tsumura & Co., it is primarily used for the treatment of influenza and the common cold, particularly in the early stages characterized by fever, chills, and joint pain. The extract's mechanism of action involves multiple components, including ephedrine and pseudoephedrine, which act as sympathomimetics, and various flavonoids and glycosides that exhibit anti-inflammatory and antiviral properties. Clinical studies have suggested that Maoto may be as effective as neuraminidase inhibitors like oseltamivir in reducing the duration of fever in influenza patients by modulating the host immune response and potentially inhibiting viral replication. In Japan, it is regulated as a pharmaceutical product and is frequently prescribed for respiratory infections.

Brand names
Maoto Tsumura
Other names
MaotoMao-toMa-huang-tangMHT
02

Targets

HA (Hemagglutinin)ADRB2 (β2)PA (Influenza virus polymerase acidic subunit)V-ATPase (Vacuolar-type H+-ATPase)

Beyond the preview

Go deeper on maoto extract.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Full profile access

Follow clinical development from study design and recruitment through results.

  • Trial phase
  • Status
  • Readouts

Indications & development

Full profile access

Explore development by indication, patient population, and geography.

  • Indications
  • Development status
  • Countries

Licensing & deals

Full profile access

Trace asset ownership, licensing agreements, and commercial partnerships.

  • Partners
  • Deal terms
  • Milestones

Patents & exclusivity

Full profile access

Explore the patent landscape and regulatory exclusivity around an asset.

  • Patents
  • Expiration dates
  • Exclusivity

Competitive landscape

Full profile access

Compare development programs by target, modality, and indication.

  • Competing assets
  • Targets
  • Development stage

Research & analysis

Full profile access

Connect source evidence and development news to your research questions.

  • Publications
  • News
  • Analysis

Bring the full picture into focus.

See how Gosset can support your research on maoto extract.

Explore the full profile

Gosset Free

Get started with Gosset.

Enter your work email and we’ll be in touch with next steps.

Work email preferred.

Book a call