Drug intelligence / Profile preview

MAR1-5A3

Development stage: Discontinued
Modality: Monoclonal Antibodies → Antibody-Based Therapeutics
Administration: Intraperitoneal, Intravenous

Overview

MAR1-5A3 is a mouse monoclonal antibody (clone MAR1-5A3) that specifically binds to and neutralizes mouse interferon-alpha/beta receptor subunit 1 (IFNAR1). It is widely used as a research-use-only (RUO) reagent to block type I interferon (IFN-I) signaling both *in vitro* and *in vivo* in mouse models. By binding to the extracellular domain of IFNAR1, MAR1-5A3 prevents the interaction of type I interferons (such as IFN-α and IFN-β) with the heterodimeric receptor complex, thereby inhibiting downstream signaling pathways. Preclinical studies have utilized MAR1-5A3 to investigate the role of type I interferon signaling in various pathological conditions, including viral infections, autoimmune diseases, and inflammatory disorders such as hemophilic arthropathy.

Other names: anti-IFNAR1 antibody clone MAR1-5A3anti-IFNAR-1 antibody clone MAR1-5A3anti-IFNAR 1 antibody clone MAR1-5A3anti-mouse IFNAR1 antibody clone MAR1-5A3clone MAR1-5A3

Targets

IFNAR1 (Interferon alpha/beta receptor 1)

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