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maraciclatide
- Development stage
- Unknown
- Lead developer
- Serac Healthcare
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptides
- Administration
- Intravenous
01
Overview
Maraciclatide is a synthetic cyclic peptide containing an RGD (Arg-Gly-Asp) motif, designed to bind with high affinity to vitronectin receptors, specifically the αvβ3 and αvβ5 integrins. When radiolabelled with technetium 99m (as 99mTc-maraciclatide), it serves as a diagnostic radiopharmaceutical for single-photon emission computed tomography (SPECT) imaging. Its primary use is in visualizing upregulated vitronectin receptors on proliferating endothelial cells, which are associated with neoplasia, cardiovascular diseases, inflammation, and endometriosis. Maraciclatide enables non-invasive detection of disease activity by targeting angiogenesis and tissue remodeling processes[1][3][5][7].
- Other names
- maraciclatide tc-99mmaraciclatide [USAN:INN]UNII-N9A1HIM7BAUNII-N-9A1HIM7BAUNII-N 9A1HIM7BA
02
Targets
αVβ3 (Integrin αVβ3)αVβ5 (Integrin αVβ5)
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