Drug intelligence / Profile preview

maraviroc + raltegravir + emtricitabine + tenofovir disoproxil fumarate

Development stage
Preclinical
Lead developer
Pfizer
Modality
Small Molecules
Administration
Oral
01

Overview

This is a four-drug combination antiretroviral therapy for HIV-1 infection. It combines: * Maraviroc: A CCR5 co-receptor antagonist that blocks HIV entry into CD4 cells * Raltegravir: An integrase strand transfer inhibitor (INSTI) that prevents HIV DNA integration * Emtricitabine: A nucleoside reverse transcriptase inhibitor (NRTI) * Tenofovir disoproxil fumarate: A nucleotide reverse transcriptase inhibitor (NtRTI) This combination provides a multi-targeted approach to HIV treatment by blocking viral entry (maraviroc), preventing viral DNA integration (raltegravir), and inhibiting viral replication (emtricitabine and tenofovir disoproxil fumarate).

02

Targets

Human immunodeficiency virus type 1 reverse transcriptaseCCR5 (C-C chemokine receptor type 5)Integrase allosteric pocket (HIV)

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