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Drug intelligence / Profile preview
maraviroc + raltegravir + emtricitabine + tenofovir disoproxil fumarate
- Development stage
- Preclinical
- Lead developer
- Pfizer
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
This is a four-drug combination antiretroviral therapy for HIV-1 infection. It combines: * Maraviroc: A CCR5 co-receptor antagonist that blocks HIV entry into CD4 cells * Raltegravir: An integrase strand transfer inhibitor (INSTI) that prevents HIV DNA integration * Emtricitabine: A nucleoside reverse transcriptase inhibitor (NRTI) * Tenofovir disoproxil fumarate: A nucleotide reverse transcriptase inhibitor (NtRTI) This combination provides a multi-targeted approach to HIV treatment by blocking viral entry (maraviroc), preventing viral DNA integration (raltegravir), and inhibiting viral replication (emtricitabine and tenofovir disoproxil fumarate).
02
Targets
CCR5 (C-C chemokine receptor type 5)Integrase allosteric pocket (HIV)Human immunodeficiency virus type 1 reverse transcriptase
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