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Marial + omeprazole
- Development stage
- Unknown
- Lead developer
- AstraZeneca
- Modality
- Device-based Delivery → Drug Delivery Systems, Small Molecules
- Administration
- Oral
01
Overview
**Marial + omeprazole** is a combination therapy used for the treatment of gastroesophageal reflux disease (GERD) and related conditions. Marial is a medical device formulation that typically includes magnesium alginate and the E-Gastryal complex (hyaluronic acid, hydrolyzed keratin, tara gum, xanthan gum, and purified water). It acts mechanically by forming a mucoadhesive film that adheres to the esophageal mucosa, providing a protective barrier against gastric acid, promoting healing, and reducing symptoms of acid reflux, heartburn, and mucosal injury. Omeprazole is a proton pump inhibitor (PPI), a small molecule drug that reduces gastric acid secretion by irreversibly blocking the H+/K+-ATPase enzyme (proton pump) on gastric parietal cells. This combination targets rapid and effective symptom control through complementary mechanisms—mechanical protection (Marial) and acid suppression (omeprazole)—and is evaluated particularly for patients with persistent reflux symptoms despite standard PPI therapy[1][2][4][6].
- Brand names
- Marial + omeprazole
- Other names
- Marial + PPIMarial + generic omeprazole
02
Targets
ATP4A (Potassium–transporting ATPase alpha chain 1)
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