marifotide

Marifotide is a synthetic nonapeptide neuroprotective agent developed by the Second Military Medical University of China for the treatment of acute ischemic stroke. It functions as a specific uncoupler of the interaction between postsynaptic density protein 95 (PSD-95) and neuronal nitric oxide synthase (nNOS). By disrupting this protein-protein interaction, marifotide prevents the overproduction of nitric oxide and subsequent excitotoxic neuronal death triggered by excessive glutamate release during an ischemic event, without interfering with the normal physiological functions of the N-methyl-D-aspartate (NMDA) receptor. This strategy aims to mitigate the downstream effects of glutamate-mediated excitotoxicity while avoiding the adverse effects typically associated with direct NMDA receptor antagonism.

Other names

YPRSSIQIF