maritoclax

**Maritoclax** (also known as marinopyrrole A) is a **natural product** isolated from marine Streptomyces species. It is a **small molecule inhibitor** that targets the anti-apoptotic protein **Mcl-1** (myeloid cell leukemia 1), a member of the Bcl-2 family of proteins. Maritoclax binds directly to Mcl-1, disrupts its interaction with the pro-apoptotic protein Bim, and induces proteasome-mediated degradation of Mcl-1. This leads to the induction of apoptosis, especially in cancer cells that rely heavily on Mcl-1 for survival. Maritoclax has shown particular effectiveness in sensitizing cancer cells (including melanoma, hematologic malignancies, and leukemia) to other therapies targeting Bcl-2 proteins (such as ABT-737), overcoming resistance associated with high Mcl-1 expression. It has also demonstrated antimicrobial activity, including activity against methicillin-resistant *Staphylococcus aureus*.[1][2][3][4][8]

Brand names

maritoclax

Other names

marinopyrrole A